Objective Analyzed the success rate, effectiveness, safety and complications of these three invasive diagnostic techniques. Method Summarized all invasive Prenatal diagnostic surgical cases of Abdominal CVS, amniocentesis and umbilical vein puncture of Guangxi MCH genetic clinics from January 2010 to December 2012. Results Three kinds of invasive prenatal diagnostic techniques can safely and effectively prevent birth defects, amniocentesis with the highest success rate ，but it is no significant difference in the miscarriage rate. Conclusions Invasive prenatal diagnosis can safe and effective in preventing birth defects, it should be widely applied.
