分类号：R714.53
出版年·卷·期（页码）：2015·7·第1期（36-39）
DOI:
10.13470/j.cnki.cjpd.2015.01.009
-----摘要：-------------------------------------------------------------------------------------------
目的 探讨孕妇巨细胞病毒（Cytomegalovirus，CMV）感染对胎儿及新生儿的影响。方法 选取2012年1月至2013年12月于本院进行规范产检的孕妇1157例，采用酶联免疫吸附试验测定孕妇外周血CMV IgG、IgM抗体，用荧光定量多聚酶链反应技术测定部分孕妇外周血和产妇乳汁中CMV DNA含量，留取新生儿外周血及尿液检测CMV DNA含量。结果 1157例孕妇血清中CMV潜伏感染率90.6%(1048/1157)，孕妇CMV活动性感染率1.6%(19/1157)，其19例新生儿先天性CMV感染的发病率为31.6%，其中1例死胎，1例无脑儿畸形；孕妇CMV潜伏感染者其新生儿先天性CMV感染有症状者的发病率为0.9%，其中黄疸并肝脾肿大4例，肺炎3例，不明原因发热并血小板减少2例。结论 孕妇活动性CMV感染导致胎儿先天性CMV感染率较高，并且可导致胎儿及新生儿不良结局。建议孕前筛查CMV感染，活动性感染者延迟怀孕，可降低CMV感染对胎儿及新生儿的不良影响。
-----英文摘要：---------------------------------------------------------------------------------------
Objective To investigate the effect of maternal cytomegalovirus infection on fetus and newborns. Method Totally 1157 pregnant women routinely examined in Qilu Hospital of Shandong University from January 2012 to December 2013 were enrolled. Enzyme-linked immunosorbent assays were applied to detect CMV specific IgG and IgM antibodies in the sera of the pregnant women. Fluorescence quantitative polymerase chain reaction was used to detect CMV DNA in neonatal peripheral blood, urine and maternal milk. Results Among 1157 pregnant women, latent infection rate was 90.6% (1048 cases). CMV-IgM positive rate was 1.6% (19/1157). The incidence of neonatal congenital infection was 31.6% in the group of active infection of pregnant women, with one case of anencephalus and another case of fetal death. In the group of latent infection of pregnant women, the rate of congenital infection was 0.9%, with four cases of jaundice and hepatosplenomegaly, three cases of pneumonia, and two cases of unexplained fever and thrombocytopenia. Conclusions Active CMV infection in pregnant women may cause higher rate of congenital CMV infection and lead to fetal and neonatal adverse outcomes. Pre-pregnancy screening of CMV infection should be recommended, and women with active CMV infection should delay pregnancy to reduce the adverse effects of CMV infection on the fetus and newborn.
-----参考文献：---------------------------------------------------------------------------------------
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桑红爱,王琳琳,刘振平,马玉燕.孕妇巨细胞病毒感染对胎儿及新生儿的影响.中国产前诊断杂志,2015,7(1):36-39.
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