孕妇血氧自由基与胎儿窘迫的关系研究 [中文引用][英文引用]

目的 分析孕妇血氧化应激指标活性氧簇（ROS）和超氧化物歧化酶（SOD）的水平，探讨其与胎儿窘迫和新生儿窒息的关系。方法 选取临产时出现胎儿窘迫的产妇为研究组，共纳入40例，另选取同期分娩时无胎儿窘迫者60例为对照组，检测两组产妇血清SOD和ROS水平，对比两组产妇氧化应激指标的差异，并采用Spearman 相关分析产妇血SOD和ROS水平与新生儿出生后的体质量和 Apgar 评分的关系。结果 研究组血清ROS和SOD水平明显高于对照组，与对照组比较差异具有统计学意义（P<0.05），ROS/SOD比值与对照组比较差异亦具有统计学意义（P<0.05）；研究组因胎儿窘迫导致新生儿窒息中，轻度窒息组中产妇血SOD水平高于重度窒息组，而重度窒息组ROS水平高于轻度窒息组（P<0.05）。相关分析显示，随着ROS/SOD比值下降，Apgar评分升高，两者呈正相关（OR=0.631，P<0.05），但与新生儿出生后的体质量未见明显相关性（P>0.05）。结论 胎儿窘迫与孕妇血清SOD和ROS水平相关，通过检测两项指标，有助于评估胎儿窘迫和新生儿窒息的程度。

Objective To analyze the levels of reactive oxygen species (ROS) and superoxide dismutase (SOD) in maternal blood oxidative stress, and to explore the relationship between them and fetal distress and neonatal asphyxia. Methods Selection of fetal distress in the time of labor for maternal team, were included in 40 cases, another selection during the same period in childbirth without fetal distress 60 cases as a control, detection of two groups of maternal serum SOD and the level of ROS, compared two groups of maternal oxidative stress indicators, and USES the Spearman correlation analysis of maternal blood SOD and ROS levels and birth after the relationship between body mass and Apgar score. Results: the serum ROS level and SOD level in the study group was significantly higher than that in the control group, the difference between the two groups was statistically significant (P<0.05), and the ROS/SOD ratio was also statistically significant (P<0.05). In the study group, maternal blood SOD level in the mild asphyxia group was higher than that in the severe asphyxia group, while ROS level in the severe asphyxia group was higher than that in the mild asphyxia group (P<0.05). Correlation analysis showed that with the decrease of ROS/SOD ratio and the increase of Apgar score, the two were positively correlated (OR=0.631, P<0.05), but there was no significant correlation with the body mass of newborn (P>0.05). Conclusion: fetal distress is related to the level of serum SOD and ROS in pregnant women.